Long Term Potentiation/Depression

Both continue to elude me… So far I have 2 preliminary conclusions or maybe just hypothesis…

  1. Both LTP/D serve to bring neurons to firing synchronization, which I actually understand as a way to determine which inputs are part of a pattern and which are not. As long as neurons fire within a certain time frame, that time frame is minimized through LTP and that minimization, dt, is the uncertainty in recognizing a pattern. LTD also is trying to bring the firing timing within that dt frame or to remove that association entirely.
  2. Both LTD/P activate when dealing with high/low frequency. Low frequency should mean not urgent, don’t propagate fast or through deep layers. High frequency means this is important, go fast and deep, reach a decision node and see if action is necessary. I also observed that high (relative) frequency overflows the neuron with too much potential the net result is that 2 different patterns with high, above threshold energy, cannot be distinguished requiring in fact an LTD event. When I deal with low frequency (presyinaptic activation that does not end up activating the presynaptic) then I delete that synapse, in multiple steps, though..

To me, the second point is difficult to reconcile, why would they be clustered to the same mechanism ? Are they the same mechanisms or appear to be the same but act on different chemicals / mechanisms…

I found a group in Israel, professor Ido Kanter‘s group. Their work seems to be very useful for my project, I could not find that kind of information anywhere else. Very much appreciated. Thank you guys.

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